Once one item is picked up the other will disappear. In the Boss Room after the Mom fight, where both The Polaroid and The Negative can be rerolled, at the cost of the opportunity to go to the Chest/ Dark Room.In the Devil Room, when there are multiple deals offered.In the Shop, when multiple items are available for purchase.Since it re-rolls every item in the room, it can be more efficient to use it in rooms where multiple items are in the same room.Isaac starts with this item once it is unlocked.Upon use, replaces every item in the current room (not pickups or trinkets) with other random items corresponding to the current room's item pool.
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